| 研究成果： |
承担项目（均为项目负责人）： 1. 国家自然科学基金面上项目：人MSL组蛋白乙酰基转移酶在乳腺癌细胞EMT和细胞分裂过程中的作用及其机制研究，2022.1—2025.12，58万。 2. 国家自然科学基金面上项目：O-GlcNAc糖基转移酶OGT在MOF/NSL组蛋白乙酰基转移酶复合物中的结构和作用研究，2016.1—2019.12，70万。 3. 国家自然科学基金面上项目：人类NSL组蛋白乙酰基转移酶的蛋白结构及其功能的研究，2012.1—2015.12,35万。 4. 吉林省科技厅重点研发项目：人参皂苷Rg3激活脐带间充质干细胞释放外泌体及其对急性心梗治疗作用的研发，2021.7—2024.6，30万。 5. 吉林省科技厅国际合作项目：OGT糖基化酶与MOF-NSL组蛋白乙酰基转移酶复合物的相互作用关系研究，2014.1—2016.12，8万。 6. 吉林省工信厅科技引导资金项目：不同间充质干细胞体外骨向诱导分化条件和生物学表征的研究及其应用，2015.1—2017.12，20万。 7. 吉林省科技厅重点科技攻关项目：肿瘤表观遗传生物标志物的研发，2013.1—2015.12，15万。 8. 高等学校博士学科点专项科研基金，博导类：hMOF组蛋白乙酰基转移酶与肿瘤发病的关系以及其分子机制的研究，2012.1—2014.12，12万。 9. 校企合作技术开发委托项目：人源间充质干细胞的生产工艺开发，2016.1—2019.1，100万。 10. 中科院（生物物理所/广州健康所）重点实验室开放课题项目：2项，共计9万。
代表性研究成果：
Wei T, Liu H, Zhu H, Chen W, Wu T, Bai Y, Zhang X, Miao Y, Wang F, Cai Y*, Jin J*. Two distinct males absent on the first (MOF)-containing histone acetyltransferases are involved in the epithelial-mesenchymal transition in different ways in human cells. Cell Mol Life Sci. 2022, 79(5):238. Liu H, Wei T, Sun L, Wu T, Li F, Zhao J, Chu J, Wang F, Cai Y*, Jin J*. The non-specific lethal (NSL) histone acetyltransferase complex transcriptionally regulates Yin Yang 1-mediated cell proliferation in human cells. Int J Mol Sci. 2022, 23(7):3801. Li Y, Li F, Feng C, Wu T, Chen Y, Shah JA, Wang F, Cai Y, Wang J and Jin Jin*. MiR-372-3p functions as a tumor suppressor in colon cancer by targeting MAP3K2. Front Genet. 2022, 13; 836256. Zhang X, Qi S, Liu D, Du J, Jin J*. PSMA-Targeted Supramolecular Nanoparticles Prepared From Cucurbit[8]uril-Based Ternary Host-Guest Recognition for Prostate Cancer Therapy. Front Chem. 2022, 10:847523. Yang Y, Zhang L, Xiong C, Chen J, Wang L, Wen Z, Yu J, Chen P, Xu Y, Jin J, Cai Y*, Li G*. HIRA complex presets transcriptional potential through coordinating depositions of the histone variants H3.3 and H2A.Z on the poised genes in mESCs. Nucleic Acids Res. 2022, 50(1):191-206. Shah JA, Khattak S, Rauf MA, Cai Y, Jin J*. Potential Biomarkers of miR-371-373 Gene Cluster in Tumorigenesis. Life (Basel). 2021, 11(9):984. Zhu H, Wang Y, Wei T, Zhao X, Li F, Li Y, Wang F, Cai Y*, Jin J*. KAT8/MOF-Mediated Anti-Cancer Mechanism of Gemcitabine in Human Bladder Cancer Cells. Biomol Ther. 2021, 29(2):184-194. Zhu H, Wei T, Cai Y, Jin J*. Small Molecules Targeting the Specific Domains of Histone-Mark Readers in Cancer Therapy. Molecules. 2020, 25(3):578. Li Y, Wang Z, Jin J, Zhu SX, He GQ, Li SH, Wang J, Cai Y*. Quercetin pretreatment enhances the radiosensitivity of colon cancer cells by targeting Notch-1 pathway. Biochem Biophys Res Commun. 2020, 523(4):947-953. Sui Y, Wu T, Li F, Wang F, Cai Y*, Jin J*. YY1/BCCIP Coordinately Regulates P53-Responsive Element (p53RE)-Mediated Transactivation of p21Waf1/Cip1. Int J Mol Sci. 2019, 20(9):2095. Wang LY, He YX, Li M, Ding J, Sui Y, Conaway JW, Conaway RC, Wang F, Jin J*, Cai Y*. DNA-dependent protein kinase catalytic subunit (DNA-PKcs) contributes to incorporation of histone variant H2A.Z into nucleosomes. Protein Cell. 2019, 10(9):694-699. Wang L, Zhao T, Wang S, Jin J, Cai Y, Wang F*. Expression, purification, and in vitro mitochondrial interaction analysis of full-length and truncated human tumor suppresser p53. Biosci Biotechnol Biochem. 2019, 83(7):1220-1226. Zhao L, Li M, Wei T, Feng C, Wu T, Shah JA, Liu H, Wang F, Cai Y*, Jin J*. O-GlcNAc-Modification of NSL3 at Thr755 Site Maintains the Holoenzyme Activity of MOF/NSL Histone Acetyltransfease Complex. Int J Mol Sci. 2019, 21(1):173. Sui Y, Li F, Wu T, Ding J, Lu Z, Wang L, Yang Y, Wang F, Zhao L, Zhu H, Wei T, Jin J*, Cai Y*. BCCIP binds to and activates its promoter in a YY1-dependent fashion in HCT116 cells. FEBS J. 2018, 285(16):3026-3040. Zhao L, Shah JA, Cai Y, Jin J*. 'O-GlcNAc Code' Mediated Biological Functions of Downstream Proteins. Molecules. 2018 Aug 6;23(8):1967. Ding J, Yu C, Sui Y, Wang L, Yang Y, Wang F, Yao H, Xing F, Liu H, Li Y, Shah JA, Cai Y*, Jin J*. The chromatin remodeling protein INO80 contributes to the removal of H2A.Z at the p53-binding site of the p21 gene in response to doxorubicin. FEBS J. 2018, 285(17):3270-3285. Wu D, Cai Y, Jin J*. Potential coordination role between O-GlcNAcylation and epigenetics. Protein Cell. 2017, 8(10):713-723. Wu D, Zhao L, Feng Z, Yu C, Ding J, Wang L, Wang F, Liu D, Zhu H, Xing F, Conaway JW, Conaway RC, Cai Y*, Jin J*. O-Linked N-acetylglucosamine transferase 1 regulates global histone H4 acetylation via stabilization of the nonspecific lethal protein NSL3. J Biol Chem. 2017, 292(24):10014-10025. Luo L, Cui J, Feng Z, Li Y, Wang M, Cai Y, Wu Y*, Jin J*. Lentiviral-mediated overexpression of KCTD12 inhibits the proliferation of human uveal melanoma OCM-1 cells. Oncol Rep. 2017, 37(2):871-878. Jiang D, Wang L, Zhao T, Zhang Z, Zhang R, Jin J, Cai Y, Wang F*. Restoration of the tumor-suppressor function to mutant p53 by Ganoderma lucidum polysaccharides in colorectal cancer cells. Oncol Rep. 2017, 37(1):594-600. Su J, Sui Y, Ding J, Li F, Shen S, Yang Y, Lu Z, Wang F, Cao L, Liu X, Jin J*, Cai Y*. Human INO80/YY1 chromatin remodeling complex transcriptionally regulates the BRCA2- and CDKN1A-interacting protein (BCCIP) in cells. Protein Cell. 2016, 7(10):749-760. Fan Z, Li D, Yu X, Zhang Y, Cai Y, Jin J, Yu J*. AIE Luminogen-Functionalized Hollow Mesoporous Silica Nanospheres for Drug Delivery and Cell Imaging. Chemistry. 2016, 22(11):3681-5. Su J, Wang F, Cai Y, Jin J*. The Functional Analysis of Histone Acetyltransferase MOF in Tumorigenesis. Int J Mol Sci. 2016, 17(1):99. Wang F, Zhao J, Liu D, Zhao T, Lu Z, Zhu L, Cao L, Yang J, Jin J*, Cai Y*. Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition. Cancer Biol Ther. 2016, 17(11):1117-1125. Sardiu ME, Gilmore JM, Groppe BD, Herman D, Ramisetty SR, Cai Y, Jin J, Conaway RC, Conaway JW, Florens L, Washburn MP. Conserved abundance and topological features in chromatin-remodeling protein interaction networks. EMBO Rep. 2015, 16(1):116-26. Zhu L, Yang J, Zhao L, Yu X, Wang L, Wang F, Cai Y*, Jin J*. Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma. Int J Oncol. 2015, 46(6):2535-45. Qin J, Cong X, Jin J, Chu Z, Gu X*, Cai Y*. Association between MDM2 SNP309 and skin cancer: A meta-analysis of case-control studies. J Dermatol Sci. 2015, 79(2):171-3. Cao L, Ding J, Dong L, Zhao J, Su J, Wang L, Sui Y, Zhao T, Wang F, Jin J*, Cai Y*. Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability. PLoS One. 2015, 10(9):e0137411. Liu D, Wu D, Zhao L, Yang Y, Ding J, Dong L, Hu L, Wang F, Zhao X, Cai Y*, Jin J*. Arsenic Trioxide Reduces Global Histone H4 Acetylation at Lysine 16 through Direct Binding to Histone Acetyltransferase hMOF in Human Cells. PLoS One. 2015, 10(10):e0141014. Yang J, Zhu L, Cai Y, Suo J, Jin J*. Role of downregulation of galectin-9 in the tumorigenesis of gastric cancer. Int J Oncol. 2014, 45(3):1313-20. Zhang R, Li X, Shi Y, Shao Y, Sun K, Wang A, Sun F, Liu W, Wang D, Jin J*, Li Y*. The effects of LPM570065, a novel triple reuptake inhibitor, on extracellular serotonin, dopamine and norepinephrine levels in rats. PLoS One. 2014, 9(3):e91775. Cao L, Zhu L, Yang J, Su J, Ni J, Du Y, Liu D, Wang Y, Wang F, Jin J*, Cai Y*. Correlation of low expression of hMOF with clinicopathological features of colorectal carcinoma, gastric cancer and renal cell carcinoma. Int J Oncol. 2014, 44(4):1207-14. Liu X, Cao L, Ni J, Liu N, Zhao X, Wang Y, Zhu L, Wang L, Wang J, Yue Y, Cai Y, Jin J*. Differential BCCIP gene expression in primary human ovarian cancer, renal cell carcinoma and colorectal cancer tissues. Int J Oncol. 2013, 43(6):1925-34. Wang Y, Zhang R, Wu D, Lu Z, Sun W, Cai Y, Wang C*, Jin J*. Epigenetic change in kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell carcinoma. J Exp Clin Cancer Res. 2013, 32(1):8. Wu D, Zhang R, Zhao R, Chen G, Cai Y*, Jin J*. A novel function of novobiocin: disrupting the interaction of HIF 1αand p300/CBP through direct binding to the HIF1αC-terminal activation domain. PLoS One. 2013, 8(5):e62014. Liu N, Zhang R, Zhao X, Su J, Bian X, Ni J, Yue Y, Cai Y*, Jin J*. A potential diagnostic marker for ovarian cancer: Involvement of the histone acetyltransferase, human males absent on the first. Oncol Lett. 2013, 6(2):393-400. Zhao X, Su J, Wang F, Liu D, Ding J, Yang Y, Conaway JW, Conaway RC, Cao L, Wu D, Wu M, Cai Y*, Jin J*. Crosstalk between NSL histone acetyltransferase and MLL/SET complexes: NSL complex functions in promoting histone H3K4 di-methylation activity by MLL/SET complexes. PLoS Genet. 2013, 9(11):e1003940. Huang K, Jia J, Wu C, Yao M, Li M, Jin J, Jiang C, Cai Y, Pei D, Pan G, Yao H*. Ribosomal RNA gene transcription mediated by the master genome regulator protein CCCTC-binding factor (CTCF) is negatively regulated by the condensin complex. J Biol Chem. 2013, 288(36):26067-26077. Capotosti F, Guernier S, Lammers F, Waridel P, Cai Y, Jin J, Conaway JW, Conaway RC, Herr W.O-GlcNAc transferase catalyzes site-specific proteolysis of HCF-1. Cell. 2011, 144(3):376-88. Chen L, Cai Y, Jin J, Florens L, Swanson SK, Washburn MP, Conaway JW, Conaway RC. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. J Biol Chem. 2011, 286(13):11283-9. Cai Y, Jin J, Swanson SK, Cole MD, Choi SH, Florens L, Washburn MP, Conaway JW, Conaway RC. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. J Biol Chem. 2010, 285(7):4268-72. |
