| 研究成果： |
近年来承担国家自然科学基金青年基金，“十二五”国家科技支撑计划，博士后科学基金特别资助项目等省部级以上项目十余项项，发表高水平SCI论文十余篇，获吉林省自然科学学术成果二等奖一项。
发表的相关论文：
1）Jiang Y (第一作者）, Bernard D, Yu Y, Zhang T, Li Y, Wang S, Fu X, and Sun D. Split Renilla Luciferase Protein-Fragment-Assisted Complementation (SRL-PFAC) to Characterize Hsp90/Cdc37 Complex and Identify Critical Residues in Protein-protein Interactions. J Biol Chem, 2010. 285(27): 21023–36.
2）Jiang Y (第一作者）, Bernard D, Yu Y, Zhang T, Li Y, Wang S, Fu X, and Sun D. Characterization of Hsp90/Cdc37 Interaction and Their Critical Residues Using Luciferase Fragment Complementation Imaging. 2010 AACR Annual Meeting, April, 2010.
3） Zhang H, Niu X, He J, Wang G and Jiang Y(通讯作者). SRL-PFAC to Evaluate Effects of Small Molecule Compounds on Hsp90/Cdc37 Interactions. Chem. Res. Chinese Universities, in press.
4）Li Y, Zhang T, Jiang Y, Lee H, Schwartz S J. and Sun D. (-)-Epigallocatechin-3-gallate Inhibits Hsp90 Function by Impairing Hsp90 Association with Cochaperones in Pancreatic Cancer Cell Line Mia Paca-2. Mol. Pharmaceutics, 2009. 6(4): 1152-9.
5）Zhang T, Li Y, Yu Y, Zou P, Jiang Y and Sun D. Characterization of Celastrol to Inhibit Hsp90 and Cdc37 Interaction. J Biol Chem, 2009. 284(51): 35381-9.
6） Li Y, Karagöz GE, Seo YH, Zhang T, Jiang Y, Yu Y, Duarte AM, Schwartz SJ, Boelens R, Carroll K, Rüdiger SG, Sun D. Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50 (Cdc37) complex and direct interactions with amino acids residues of Hsp90. J Nutr Biochem，2012 Mar 22. [Epub ahead of print]
|
