| 研究成果： |
承担项目
项目名称：“构建上转换荧光纳米粒子标记的多肽芯片应用于蛋白酶活性检测和抑制剂筛选”， 国家自然科学青年基金（2012年），获得资助25万，项目申请者和负责人。(Grant No.21205113)
代表论文
1) Xuefeng Xing, Wanyao Liu, Tao Li*, Shu Xing, Xueqi Fu, Dongyang Wu, Dianjun Liu, Zhenxin Wang*, Portable Optical Waveguide Resonance Light-Scattering Scanner for Microarray Detection. Analyst, 2016, 141, 199.
2) Tao Li, Min Su, Lan Ma, Zhenxin Wang* Studying chemical-regulation of intracellular kinase activity by peptide microarray-based assay with gold nanoparticle probes. Anal. Methods. 2014, 23, 9404-9409.
3) Min Su, Tao Li*, ZhenXin Wang*. A Peptide Microarray-Based Fluorescent and Resonance Light Scattering Assay for Screening Thrombin Inhibitor. Chin J Anal Chen, 2015, 43, 199-206.
4) Tao Li , Xia Liu , Dianjun Liu, Zhenxin Wang* Sensitive Detection of Protein Kinase A Activity in Cell Lysates by Peptide Microarray-Based Assay. Anal. Chem., 2013, 85, 7033–7037.
5) Min Su, Lan Ma, Tao Li*, Dianjun Liu, Zhenxin Wang* A microarray-based resonance light scattering assay for detecting thrombin generation in human plasma by gold nanoparticle probes. Anal. Methods, 2013,5, 5895-5898.
6) Tao Li, Dianjun Liu and Zhenxin Wang*, Screening kinase inhibitors with microarray-based Raman spectroscopic assay. Anal. Methods, 2011, 3, 1003-1007.
7) Tao Li, Dianjun Liu, Zhenxin Wang*, Screening Kinase Inhibitors with a Microarray-Based Fluorescent and Resonance Light Scattering Assay. Anal. Chem. 2010, 82, 3067-3072.
8) Tao Li, Dianjun Liu, Zhenxin Wang*, Microarray-Based Raman Spectroscopic Assay for Kinase Inhibition by Gold Nanoparticle Probes. Biosens. Bioelectron. 2009, 24, 3335-3339.
9) Tao Li, Liping Guo, Zhenxin Wang*, Microarray based Raman spectroscopic detection with gold nanoparticle probes. Biosens. Bioelectron. 2008, 23, 1125-1130.
10) Tao Li, Liping Guo, Zhenxin Wang*, Gold Nanoparticle-based Surface Enhanced Raman Scattering Spectroscopic Assay for the Detection of Protein–Protein Interactions. Anal. Science 2008, 24, 907-910.
11) Junping Zhang， Fuyao Liu， Xiuxia He，Tao Li, Zhenxin Wang*, Surface charge effect on the cellular interactionand cytotoxicity of NaYF4:Yb3+,Er3+@SiO2nanoparticles，RSC Advances，2015, 5, 7773-7780.
12) Lan Ma, Zhijun Zhu，Tao Li，Zhenxin Wang*, Assaying multiple restriction endonucleases functionalities and inhibitions on DNA microarray with multifunctional gold nanoparticle probes，Biosens. Bioelectron.，2014, 52, 118-123.
13) Lan Ma， Min Su，Tao Li， Zhenxin Wang *, Microarray-based resonance light scattering assay for detecting DNA methylation and human DNA methyltransferase simultaneously with high sensitivity，Analyst，2014, 139, 3537-3540.
14) Lan Ma, Min Su, Tao Li， Zhenxin Wang *, Microarray-based fluorescence assay of endonuclease functionality and inhibition，Analyst，2013, 138, 1048-1052.
15) Xia Liu, Tao Li， Dianjun Liu, Zhenxin Wang*，Fabricating three-dimensional hydrogel oligonucleotide microarrays to detect single nucleotide polymorphisms，Anal. Methods，2013, 5, 285~290.
16) Xuefeng Xing， Xia Liu，Tao Li， Zhenxin Wang*, Development of Light Waveguide Resonance Light-Scattering Scanner for Microarray Detection，Chin J Anal Chen，2013, 41, 1458-1462.
17) Dawei Wang, Tao Li， Yang Liu, Jianshe Huang, Tianyan You *, Large-Scale and Template-Free Growth of Free-Standing Single-Crystalline Dendritic Ag/Pd Alloy Nanostructure Arrays. Cryst. Growth. Des., 2009, 9, 4351-4355.
发明专利
（1）‘DNA微阵列芯片检测与Ⅱ型糖尿病相关的单核苷酸多态性的方法’
ZL201410628972.5，2017年9月22日
（2）‘基于共振光散射检测生物芯片的装置’ZL201310025477.0，2015年5月20日
获奖情况
2012年获吉林省科学技术进步二等奖（排名3） |
