| 研究成果： |
主持的科研项目：
1. 题目：基于肿瘤微环境设计构建抗癌肽的靶向缓释体系
吉林省自然科学基金 起止时间：2018.1.1-2020.12.31
2. 题目：pH敏感型抗癌肽靶向缓释体系的构建与评估
吉林省教育厅“十三五”科学技术项目
起止时间：2018.1.1-2019.12.31
3. 题目：PL-AC的活性筛选及作用机理研究
江苏普莱医药生物技术有限公司 起止时间：2018.7.1-2022.6.30
4. 题目：抗癌肽-阿霉素共组装靶向缓释微球的抗癌作用研究
国家自然科学基金 起至时间：2015.1-2015.12
5. 题目：利用多肽自组装构建抗癌药物的靶向缓释模型
吉林省自然科学基金 起至时间：2014.1-2016.12
6. 题目：国家Ⅰ类抗菌新药乐舒肽检测方法研究
长春普莱医药生物技术有限公司 起至时间：2012.3-2014.3
7. 题目：设计DL杂合多肽研究螺旋型抗癌肽的抗癌作用机理
中国博士后科学基金 起至时间：2011.8-2012.8
8. 题目：螺旋度对抗癌肽活性的贡献及其抗肿瘤作用机理的研究
吉林省青年基金 起至时间：2010.9-2012.9
9. 题目：RGD（S）靶向磁载纳米微球的制备及其抗癌作用的研究
高等学校博士学科点专项科研基金（新教师基金） 教育部
起至时间：2007.1-2009.12
科技奖励：
2017.11 吉林省自然科学奖二等奖 第二完成人
2014.11 吉林省自然科学学术成果奖 第二完成人
2012.11 吉林省科技进步三等奖 第二完成人
代表性论文：
1）Yibing Liu, Xu He, Pinyi Ma*, Yibing Huang*, Xiaolei Li, Ying Sun, Xinghua Wang,Daqian Song*. Talanta, 2020, 217:121081.
2) Yibing Liu, Fangmei Zhang, Xu He, Pinyi Ma*, Yibing Huang*, Shuo Tao, Ying Sun, Xinghua Wang, Daqian Song* A novel and simple fluorescent sensor based on AgInZnS QDs for the detection of protamine and trypsin and imaging of cells. Sensors & Actuators: B. Chemical . 2019, 294 : 263–269
3) Ran Liu, Yangyue Ni, Jingwei Song, Zhipeng Xu*, Jingfan Qiu, Lijuan Wang, Yuxiao Zhu, Yibing Huang*, Minjun Ji, Yuxin Chen. Research on the effect and mechanism of antimicrobial peptides HPRP-A1/ A2 work against Toxoplasma gondii infection. Parasite Immunology. 2019, 41: e12619.
4)Hu C, Ma N, Li F, Fang Y, Liu Y, Zhao L, Qiao S, Li X, Jiang X, Li T, Shen F, Huang Y*, Luo Q*, Liu J. Cucurbit[8]uril-Based Giant Supramolecular Vesicles: Highly Stable, Versatile Carriers for Photoresponsive and Targeted Drug Delivery. ACS Appl Mater Interfaces. 2018,10(5):4603-4613.
5)Zhao W, Han L, Peng Y, Wang X, Liu S, Li P, Huang Y*, Chen Y. The Effect of Basic Amino Acids on the Biological Activity of Helical Antimicrobial Peptide. Chem. J. Chin. Univ, 2018, 39:681-687.
6)Yan, Q.Y., Hao,X.Y., Huang, Y.B.*, Chen, Y.X.*. Self-assembly of alpha-helical cationic antimicrobial peptide with different length of hydrophobic alkyl tails.Nanomedicine: Nanotechnology, Biology, and Medicine ,2016,12 : 552-552.
7)Zhao J, Hao X, Liu D, Huang Y*, Chen Y*, In vitro characterization of the rapid cytotoxicity of anticancer peptide HPRP-A2 through membrane destruction and intracellular mechanism against gastric cancer cell lines. PLoS One, 2015, 10(9), e0139578.
8)Hao X, Yan Q, Zhao J, Wang W, Huang Y*, Chen Y*, TAT modification of alpha-helical anticancer peptides to improve specificity and efficacy. PLoS One, 2015, 10(9), 0138911
9)Huang Y B, Feng Q, Yan Q Y, Hao X Y and Chen Y X*, Alpha-helical cationic anticancer peptides: a promising candidate of novel anticancer drugs. Mini-Rev. Med. Chem., 2015, 15(1), 73-81.
10)Huang Y, He L, Li G, Zhai N, Jiang H*, Chen Y*, Role of helicity of α-helical antimicrobial peptides to improve specificity. Protein Cell, 2014, 5(8), 631-642.
11)Huang Y, Pan L, Zhao L, Mant CT, Hodges RS, Chen Y*, Structure-guided RP-HPLC chromatography of diastereomeric α-helical peptide analogs substituted with single amino acid stereoisomers. Biomed Chromatogr., 2014, 28, 511–517.
12)Huang Y B, Shi J F, Yuan D, Zhou N, Xu B*, Length-dependent proteolytic cleavage of short oligopeptides catalyzed by matrix metalloprotease-9. Biopolymers: Peptide Sci., 2013, 100(6), 790-795. (Co-author)
13)Liu X, Huang Y, Cheng M, Pan L, Si Y, Li G, Niu Y, Zhao L, Zhao J, Li X, Chen Y*, Yang W*, Screening and rational design of HCV entry inhibitory peptides derived from GBV-A NS5A. J Virol., 2013，87(3), 1649-1657. (Co-author)
14)Huang YB, He LY, Jiang HY*, Chen YX*, Role of helicity on the anticancer mechanism of action of cationic-helical peptides. Int. J. Mol. Sci., 2012, 13, 6849-6862.
15)Huang YB, Zhai NC, Gao G, Chen YX*. Effects of Net Charge on Biological Activities of Alpha helical Anticancer Peptides. Chem. J. Chin. Univ. 2012, 33 (6): 1252-1258
16)Huang YB, Wang XF, Wang HY, Liu Y*, Chen YX*, Studies on mechanism of action of anticancer peptides by modulation of hydrophobicity within a defined structural framework. Molecular Cancer Therapeutics, 2011, 10,416-426.
17)Huang YB, Huang JF, Chen YX*, Alpha-helical cationic antimicrobial peptides: relationships of structure and function. Protein & Cell, 2010, 1, 143-152.
18)Huang YB, Yang S, Cai Y, Wang H, Gao G, Wu XX, Xu Li*, Zhang XZ*, Alcalase-catalysed synthesis of the presursor tetrapeptide N-benzoylarginylglycylaspartylserinamide (Bz-RGDS-NH2) of the cell-adhesion peptide argininylglycylaspartylserine (RGDS)，Biotechnol. Appl. Bioc. 2008, 51（3）：119-127
19)Huang YB, Cai Y, Yang S, Wang H, Hou RZ, Xu L, Wu XX , Zhang XZ*. Synthesis of tetrapeptide Bz-RGDS-NH2 by a combination of chemical and enzymatic methods. J Biotechnol, 2006，125(3):311-318
20)Huang YB, Cai Y, Yang S, Wang H, Hou RZ, Xu L, Wu XX , Zhang XZ*. Chemo-enzymatic synthesis of precursor tetrapeptide Bz-RGDS-NH2 of cellular adhesion motif in low water organic media. Enzyme Microb.Techn., 2006，39 (5): 1150-1165
21)Huang YB, Xiao YP, Wang H, Hou RZ, Zhang N, Wu XX, Xu L, Zhang XX*, Chemo-enzymatic synthesis of tripeptide RGD diamide in organic solvents. J Biotechnol, 2005，116(1): 51-59 |
